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Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse: Data set from publication Henstridge et al 2015 Acta Neuropath Comms

Henstridge, Christopher M; Jackson, Rosemary J; Kim, JeeSoo M; Herrmann, Abigail G; Wright, Ann K; Harris, Sarah; Bastin, Mark E; Starr, John M; Wardlaw, Joanna; Gillingwater, Thomas H; Smith, Colin; McKenzie, Chris-Anne; Cox, Simon R; Deary, Ian J; Spires-Jones, Tara L

Non-pathological, age-related cognitive decline varies markedly between individuals and places significant financial and emotional strain on people, their families and society as a whole. Understanding the differential ...

Non-fibrillar oligomeric amyloid-β within synapses: Data set from publication Pickett et al 2016 J Alz Dis

Pickett, Eleanor K; Koffie, Robert M; Wegmann, Susanne; Henstridge, Christopher M; Herrmann, Abigail G; Colom-Cadena, Marti; Lleo, Alberto; Kay, Kevin R; Vaught, Melissa; Soberman, Roy; Walsh, Dominic M; Hyman, Bradley T; Spires-Jones, Tara L

Alzheimer’s disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration and the extracellular accumulation of amyloid-beta (Ab) peptide in senile plaques and intracellular accumulation ...