One Health is the approach underpinning the research done at the Edinburgh Medical School. The modern challenges that face not only the UK but the world in terms of the rise of chronic disease, the shifts in populations and the challenges presented by a population which is living much longer are common and the mechanisms underpinning them are common. The aim of the School is to bring the right individuals together to catalyse and create the opportunities to really develop exciting and cutting edge clinical and non-clinical research that makes a difference to people’s lives.

Edinburgh Medical School

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  • Dataset concerning the manuscript "Rare variants implicate ENPP6 as a regulator of reduced visceral adiposity" 

    Schraut, Katharina; Wilson, James F
    The Orkney Complex Disease Study (ORCADES) is a family-based population cohort with DNA, biological samples, and a wide range of clinical data from ~2,000 adult volunteers from the Orkney Islands. Genotype data is also ...
  • Stellate cells in medial entorhinal cortex are required for spatial learning 

    Tennant, Sarah; Garden, Derek; Gerlei, Klara; Martinez-Gonzalez, Cristina; McClure, Christina; Wood, Emma; Nolan, Matthew
    Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest ...
  • Generation Scotland SFHS Data Dictionary 

    Campbell, Archie; Kerr, Shona; Porteus, David
    The GS:SFHS Data Dictionary is a set of information describing the contents, format, and structure of the phenotype data collected during recruitment (2006-2011) to the Generation Scotland Scottish Family Health Study ...
  • Central cornea thickness Genome Wide Association Meta Analyses - Summary statistics 

    Iglesias, Adriana I.; Mishra, Aniket; Vitart, Veronique; van Duijn, Cornelia M.; MacGregor, Stuart; on behalf of the "International Glaucoma Genetics Consortium"
    Results from the meta-analyses of genome-wide association studies for central cornea thickness in human. Corneal thinning is a common feature of rare Mendelian connective tissue disorders, such as Ehlers-Danlos syndrome ...
  • Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Array tomography data 

    Spires-Jones, Tara L; Henstridge, Christopher M
    We provide the raw array tomography data that was analysed for the publication "Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis", published in Acta Neuropathologica ...
  • Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Analysis macros 

    Henstridge, Christopher M; Spires-Jones, Tara L
    In addition to motor neurone degeneration, up to 50% of Amyotrophic Lateral Sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, ...
  • Long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T 

    Thrippleton, Michael J; Parikh, Jehill P; Semple, Scott I K; Harris, Bridget A; Andrews, Peter J D; Wardlaw, Joanna M; Marshall, Ian
    Figures from article, "Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T", accepted (December 2017) for publication in PlosONE. Figure 1 shows a brain slice and ...
  • Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers 

    Young, Robert; Taylor, Martin
    Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as ...
  • Epidemiological characteristics of human-infective RNA viruses 

    Woolhouse, Mark; Brierley, Liam
    RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a period of 18 years, we provide a catalogue of all 214 known human-infective RNA virus species. We link these ...
  • SUPERSEDED - Epidemiological characteristics of human-infective RNA viruses 

    Woolhouse, Mark; Brierley, Liam
    ## This data item has been replaced by the one which can be found at http://dx.doi.org/10.7488/ds/2265 . ## RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a ...
  • Data on selection against BALB/c strain cells in mouse chimaeras 

    Tang, Pin-Chi; MacKay, Gillian E; Flockhart, Jean H; Keighren, Margaret A; Kopakaki, Anna; West, John D
    The data are numerical data used to produce Figs. 2, 3 & 4 and Supplementary Tables S1, S2 & S3 in a manuscript entitled "Selection against BALB/c strain cells in mouse chimaeras" by Tang P-C, Mackay GE, Flockhart JH, ...
  • Edinburgh_NIH10 

    Bastin, Mark E; Wardlaw, Joanna; Pernet, Cyril R; Mikhael, Shadia
    This data set contains 10 normal healthy subjects ('sub-001' to 'sub-010') from a larger NIH funded project (NIH grant R01 EB004155) investigating changes in water diffusion parameters with age. Subjects underwent structural ...
  • Code and datasets for structural analyses in Natan et al, "Assembly in the translation milieu imposes evolutionary constraints on homomeric proteins" 

    Marsh, Joseph
    This contains datasets and Perl scripts needed to reproduce the figures in Natan et al "Assembly in the translation milieu imposes evolutionary constraints on homomeric proteins". Specifically, it can be used to calculate ...
  • 3D mouse embryo model: EMA76, Stage TS20, Age E12.0 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA77, Stage TS20, Age E12.0 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA146, Stage TS21, Age E13.0 (est) 

    Ruffins, Seth; Jacobs, Russell; Armit, Chris; Burton, Nick; Hill, Bill; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA37, Stage TS15, Age E9.5 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA71, Stage TS19, Age E11.5 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA31, Stage TS15, Age E9.5 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA41, Stage TS16, Age E10.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...

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