Edinburgh Medical School
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One Health is the approach underpinning the research done at the Edinburgh Medical School. The modern challenges that face not only the UK but the world in terms of the rise of chronic disease, the shifts in populations and the challenges presented by a population which is living much longer are common and the mechanisms underpinning them are common. The aim of the School is to bring the right individuals together to catalyse and create the opportunities to really develop exciting and cutting edge clinical and non-clinical research that makes a difference to people’s lives.
Image: CC-BY Mikhael, S dx.doi.org/10.7488/ds/1576
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John West's Research Group
Corneal epithelium research
Recent Submissions
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Genomic underpinnings of lifespan allow prediction and reveal basis in modern risks
We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, ... -
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data
Of all of the neuropathological changes observed in Alzheimer's disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise mechanisms of synapse degeneration in AD remain unclear, ... -
Thesis Movies - 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'
Movies for the doctoral thesis 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'. -
Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1)
This is a pilot study looking at the effect of Gabapentin in women with chronic pelvic pain. Participants were assigned at random to the placebo or the drug group. The design follows procedure of double blinding, i.e. ... -
Structural, functional and metabolic brain differences between groups with opposite gender identity and sexual orientation. A systematic review on the neuroimaging literature up to 2018
Human sexuality is a complex reality, characterised by gender identity and sexual orientation. A widespread approach to study human sexuality is to compare groups with opposite sexual gender identity and sexual orientation ... -
Proteomics datasets from Shorrock et al (UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy)
Detailed proteomics data files from Shorrock et al., 2018 'UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy' (Accepted manuscript to be published in Brain). -
A Manual Segmentation Protocol for Cortical Gyri
This protocol provides a guideline for outlining the superior frontal gyrus (SFG), the supramarginal gyrus (SMG) and the cingulate gyrus (CG). It is based on a thorough revision of 2 atlases: (1) the Duvernoy atlas, a ... -
Images for "Functional Transport of Organic Anions and Cations in the Murine Mesonephros"
The mesonephros of mammals is a transient renal structure that contributes to various aspects of mammalian fetal development including the male reproductive system, hematopoietic stem cells and vascular endothelial cells. ... -
Morphometric data for Edinburgh_NIH10 dataset - all package runs
This data consists of morphometric measurements for the 10 subjects of the Edinburgh_NIH10 dataset (http://dx.doi.org/10.7488/ds/2239) as well as Matlab code written to derive some statistics for these measurements. The ... -
Supplementary files for study on modeling DSB with random forests
Structural variants (SVs) are known to play important roles in a variety of cancers, but their origins and functional consequences are still poorly understood. The nonrandom distributions of these variants across tumour ... -
Morphometric data for Edinburgh_NIH10 dataset
This data consists of morphometric measurements for the 10 subjects of the Edinburgh_NIH10 dataset (http://dx.doi.org/10.7488/ds/2239) as well as Matlab code written to derive some statistics for these measurements. The ... -
Role of accelerated ageing in limb muscle wasting of patients with Chronic Obstructive Pulmonary Disease (COPD)
Skeletal muscle wasting is an independent predictor of health-related quality of life, and survival in COPD, but the complexity of the molecular mechanisms associated with this process have not been fully elucidated. We ... -
Data from computer simulation of neutral drift among limbal epithelial stem cells of mosaic mice
It was previously shown that limbal epithelial stem cells (LESCs) around the periphery of the cornea maintain radial sectors of the corneal epithelium but that radial stripe numbers declined with age in mosaic mice. ... -
Research Plan - The effect of APOE genotype on microglial-mediated synapse loss in AD
This is a pre-registration of an experimental plan to examine the effect of APOE genotype on microglial-mediated synapse loss in Alzheimer's disease. There is now extensive literature covering synapse loss in AD and mouse ... -
Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease - rodent datasets
Network hyperexcitability is a feature of Alzheimer's disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic ... -
Kidney vascularisation reviews - summary table
Excel sheet containing a summary of reviews discussing vasculogenesis and angiogenesis in the developing kidney. This is a partner file for the article 'Mechanisms of kidney vascularization: what can natural development ... -
Supplementary Data to "Ligand binding site structure influences the evolution of protein complex function and topology" by G. Abrusan and J.A. Marsh
It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding ... -
Masks2Metrics (M2M) 1.0: a Matlab tool for region-of-interest metrics
Masks2Metrics (M2M) is a Matlab based tool that is used to calculate 3 metrics for a given region-of-interest (ROI) in a 3D image: thickness, volume and surface area. While many software packages that automatically compute ... -
Dataset concerning the manuscript "Rare variants implicate ENPP6 as a regulator of reduced visceral adiposity"
The Orkney Complex Disease Study (ORCADES) is a family-based population cohort with DNA, biological samples, and a wide range of clinical data from ~2,000 adult volunteers from the Orkney Islands. Genotype data is also ... -
Stellate cells in medial entorhinal cortex are required for spatial learning
Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest ...
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