Edinburgh Medical School
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One Health is the approach underpinning the research done at the Edinburgh Medical School. The modern challenges that face not only the UK but the world in terms of the rise of chronic disease, the shifts in populations and the challenges presented by a population which is living much longer are common and the mechanisms underpinning them are common. The aim of the School is to bring the right individuals together to catalyse and create the opportunities to really develop exciting and cutting edge clinical and non-clinical research that makes a difference to people’s lives.
Image: CC-BY Mikhael, S dx.doi.org/10.7488/ds/1576
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John West's Research Group
Corneal epithelium research
Recent Submissions
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Morphometric data for Edinburgh_NIH10 dataset
This data consists of morphometric measurements for the 10 subjects of the Edinburgh_NIH10 dataset (http://dx.doi.org/10.7488/ds/2239) as well as Matlab code written to derive some statistics for these measurements. The ... -
Role of accelerated ageing in limb muscle wasting of patients with Chronic Obstructive Pulmonary Disease (COPD)
Skeletal muscle wasting is an independent predictor of health-related quality of life, and survival in COPD, but the complexity of the molecular mechanisms associated with this process have not been fully elucidated. We ... -
Data from computer simulation of neutral drift among limbal epithelial stem cells of mosaic mice
It was previously shown that limbal epithelial stem cells (LESCs) around the periphery of the cornea maintain radial sectors of the corneal epithelium but that radial stripe numbers declined with age in mosaic mice. ... -
Research Plan - The effect of APOE genotype on microglial-mediated synapse loss in AD
This is a pre-registration of an experimental plan to examine the effect of APOE genotype on microglial-mediated synapse loss in Alzheimer's disease. There is now extensive literature covering synapse loss in AD and mouse ... -
Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease - rodent datasets
Network hyperexcitability is a feature of Alzheimer's disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic ... -
Kidney vascularisation reviews - summary table
Excel sheet containing a summary of reviews discussing vasculogenesis and angiogenesis in the developing kidney. This is a partner file for the article 'Mechanisms of kidney vascularization: what can natural development ... -
Supplementary Data to "Ligand binding site structure influences the evolution of protein complex function and topology" by G. Abrusan and J.A. Marsh
It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding ... -
Masks2Metrics (M2M) 1.0: a Matlab tool for region-of-interest metrics
Masks2Metrics (M2M) is a Matlab based tool that is used to calculate 3 metrics for a given region-of-interest (ROI) in a 3D image: thickness, volume and surface area. While many software packages that automatically compute ... -
Dataset concerning the manuscript "Rare variants implicate ENPP6 as a regulator of reduced visceral adiposity"
The Orkney Complex Disease Study (ORCADES) is a family-based population cohort with DNA, biological samples, and a wide range of clinical data from ~2,000 adult volunteers from the Orkney Islands. Genotype data is also ... -
Stellate cells in medial entorhinal cortex are required for spatial learning
Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest ... -
Generation Scotland SFHS Data Dictionary
The GS:SFHS Data Dictionary is a set of information describing the contents, format, and structure of the phenotype data collected during recruitment (2006-2011) to the Generation Scotland Scottish Family Health Study ... -
Central cornea thickness Genome Wide Association Meta Analyses - Summary statistics
Results from the meta-analyses of genome-wide association studies for central cornea thickness in human. Corneal thinning is a common feature of rare Mendelian connective tissue disorders, such as Ehlers-Danlos syndrome ... -
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Array tomography data
We provide the raw array tomography data that was analysed for the publication "Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis", published in Acta Neuropathologica ... -
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Analysis macros
In addition to motor neurone degeneration, up to 50% of Amyotrophic Lateral Sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, ... -
Long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T
Figures from article, "Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T", accepted (December 2017) for publication in PlosONE. Figure 1 shows a brain slice and ... -
Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers
Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as ... -
Epidemiological characteristics of human-infective RNA viruses
RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a period of 18 years, we provide a catalogue of all 214 known human-infective RNA virus species. We link these ... -
SUPERSEDED - Epidemiological characteristics of human-infective RNA viruses
## This data item has been replaced by the one which can be found at http://dx.doi.org/10.7488/ds/2265 . ## RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a ... -
Data on selection against BALB/c strain cells in mouse chimaeras
The data are numerical data used to produce Figs. 2, 3 & 4 and Supplementary Tables S1, S2 & S3 in a manuscript entitled "Selection against BALB/c strain cells in mouse chimaeras" by Tang P-C, Mackay GE, Flockhart JH, ... -
Edinburgh_NIH10
This data set contains 10 normal healthy subjects ('sub-001' to 'sub-010') from a larger NIH funded project (NIH grant R01 EB004155) investigating changes in water diffusion parameters with age. Subjects underwent structural ...
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