Edinburgh Medical School
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One Health is the approach underpinning the research done at the Edinburgh Medical School. The modern challenges that face not only the UK but the world in terms of the rise of chronic disease, the shifts in populations and the challenges presented by a population which is living much longer are common and the mechanisms underpinning them are common. The aim of the School is to bring the right individuals together to catalyse and create the opportunities to really develop exciting and cutting edge clinical and non-clinical research that makes a difference to people’s lives.
Image: CC-BY Mikhael, S doi.org/10.7488/ds/1983
Sub-communities within this community
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Molecular, Genetic and Population Health Sciences
Institute of Genetics and Molecular Medicine and Usher Institute
Collections in this community
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John West's Research Group
Corneal epithelium research
Recent Submissions
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Protein genome-wide associations from the paper 'Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits'.
Data in support of the manuscript "Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits". -
Dementia risk prediction model - definitions of variables
List of ICD-10 and Read version 2 codes used to define predictor and outcome variables for dementia risk prediction model. -
Global seasonality of human seasonal coronaviruses
Background It is speculated that the ongoing pandemic of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 virus could recur as seasonal outbreaks, a circulating pattern observed among other pre-existing human ... -
Exploratory use of fluorescent SmartProbes for the rapid detection of microbial isolates causing corneal ulcer
# Purpose # To explore the use of optical SmartProbes for the rapid evaluation of corneal scrapes from patients with suspected microbial keratitis, as a clinical alternative to Gram stain. # Design # Experimental ... -
Molecular Detection of Gram-positive Bacteria in the Human Lung through an Optical Fiber Based Endoscope
# Purpose # The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this, we ... -
National burden estimates of hospitalisations for acute lower respiratory infections due to respiratory syncytial virus in 2020: the Burden of Influenza and RSV Disease (BIRD) study
Abstract Background Respiratory syncytial virus (RSV) is the predominant viral pathogen associated with acute lower respiratory infection (ALRI) in children under five years of age (<5y). Little is reported on the national ... -
Variant effect predictions for human, yeast, bacterial and viral proteins
Variant effect predictions made by DEOGEN2, Envision, FATHMM, Fathmm-MKL, FathmmXF, MPC, MutationTaster, MutPred, NetDiseaseSNP, PhD_SNP, PolyPhen2 (HumDiv and HumVar), PonPS, PonP2, PrimateAI, S3D-PROF, SNAP2, SNPs&GO, ... -
VEP predictions for ClinVar and gnomAD variants
Variant effect predictions and DMS data for ClinVar and gnomAD variants in BRCA1, P53, CALM1, PTEN, HRAS and TPK1. -
Genome-wide association summary statistics of antidepressant treatment resistance meta-analysis
Data from Wigmore et al "Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP". The Pharmacogenomics Journal ... -
Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
Ageing phenotypes, such as years lived in good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (longevity), are of interest to us all but require exceptionally large sample sizes ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference. Donepezil administration
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cortex reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
J20 rodent EEG and video recordings
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 8 month rodent EEG and video recordings
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
DICOM imaging data sets, CT and PET. Distribution and kinetics of [18F]AB5186 in rats. -
Global burden of respiratory infections associated with seasonal influenza in young children in 2018: a systematic review and modelling study
# Background # Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-v ... -
Medication-wide association study of dementia
Dataset from medication-wide association study of dementia, using the Secure Anonymised Information Linkage databank Dementia electronic Cohort (SAIL-DeC). This dataset contains the hazard ratios and p-values for all ... -
Motyl AAL, et al. (2020). Pre-symptomatic developmental phenotypes in Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a leading genetic cause of infant death, characterised primarily by a loss of lower motor neurons. SMA is caused by mutations in the survival motor neuron 1 (SMN1) gene. New SMN-restoring ... -
Cost of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection Management in Young Children at the Regional and Global Level: A Systematic Review and Meta-Analysis
This is the first systematic review and meta-analysis summarizing the current evidence related to the cost of RSV disease among children below 5 years of age. It demonstrates that the economic burden associated with RSV ...
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