Edinburgh Medical School
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One Health is the approach underpinning the research done at the Edinburgh Medical School. The modern challenges that face not only the UK but the world in terms of the rise of chronic disease, the shifts in populations and the challenges presented by a population which is living much longer are common and the mechanisms underpinning them are common. The aim of the School is to bring the right individuals together to catalyse and create the opportunities to really develop exciting and cutting edge clinical and non-clinical research that makes a difference to people’s lives.
Image: CC-BY Mikhael, S dx.doi.org/10.7488/ds/1576
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John West's Research Group
Corneal epithelium research
Recent Submissions
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Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis
Background: Influenza virus (IFV), respiratory syncytial virus (RSV), parainfluenza virus (PIV), and metapneumovirus (MPV) are the most common viruses associated with acute lower respiratory infections in young children ... -
The etiological role of common respiratory viruses in acute respiratory infections in older adults: A systematic review and meta-analysis
Acute respiratory tract infections (ARI) constitute a substantial disease burden in adults and elderly individuals. We aimed to identify all case-control studies investigating the potential role of respiratory viruses in ... -
Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 2015: A systematic review and meta-analysis
Respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years. We aimed to identify all studies worldwide investigating the disease ... -
Global and regional burden of hospital admissions for pneumonia in older adults: A systematic review and meta-analysis
Pneumonia constitutes a substantial disease burden among adults overall and those who are elderly. We aimed to identify all studies investigating the disease burden among older adults (age, ≥65 years) admitted to the ... -
Best practice for fMRI displays, plots and colour maps
Sets of illustrations for best practices in displaying tomographic imaging data - applied here to functional MRI. Images either shows different ways to present the data or show various colour maps with luminance correction. -
Data and Code for "Fibre-based Spectral Ratio Endomicroscopy for Contrast Enhancement of Bacterial Imaging and Pulmonary Autofluorescence"
Fibre-based optical endomicroscopy (OEM) permits high resolution fluorescence microscopy in endoscopically accessible tissues. Fibred OEM has the potential to visualise pathologies targeted with fluorescent imaging probes ... -
SAIL dementia e-cohort (SAIL-DeC)
These files contain details on the creation of the Secure Anonymised Information Linkage (SAIL) databank dementia e-cohort (SAIL-DeC). -
Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics
This dataset contains summary statistics for the epigenome-wide association studies (EWASs) performed to ascertain the feasibility of profiling DNA methylation using dried blood spot (DBS) DNA from Generation Scotland ... -
Supplementary data to "Ligand binding site structure shapes allosteric signal transduction and the evolution of allostery in protein complexes" by G. Abrusan and J.A. Marsh
The structure of ligand binding sites has been shown to profoundly influence the evolution of function in homomeric protein complexes. Complexes with multi-chain binding sites (MBSs) have more conserved quaternary structure, ... -
GWAS summary statistics for UPLC IgG N-glycosylation traits
The majority of proteins undergo post-translational glycosylation, in which complex carbohydrates are attached to the surface of proteins. However, when studying glycoproteins, the glycan component is often neglected. ... -
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, ... -
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data
Of all of the neuropathological changes observed in Alzheimer's disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise mechanisms of synapse degeneration in AD remain unclear, ... -
Thesis Movies - 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'
Movies for the doctoral thesis 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'. -
Structural, functional and metabolic brain differences between groups with opposite gender identity and sexual orientation. A systematic review on the neuroimaging literature up to 2018
Human sexuality is a complex reality, characterised by gender identity and sexual orientation. A widespread approach to study human sexuality is to compare groups with opposite sexual gender identity and sexual orientation ... -
Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1)
This is a pilot study looking at the effect of Gabapentin in women with chronic pelvic pain. Participants were assigned at random to the placebo or the drug group. The design follows procedure of double blinding, i.e. ... -
Proteomics datasets from Shorrock et al (UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy)
Detailed proteomics data files from Shorrock et al., 2018 'UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy' (Accepted manuscript to be published in Brain). -
A Manual Segmentation Protocol for Cortical Gyri
This protocol provides a guideline for outlining the superior frontal gyrus (SFG), the supramarginal gyrus (SMG) and the cingulate gyrus (CG). It is based on a thorough revision of 2 atlases: (1) the Duvernoy atlas, a ... -
Images for "Functional Transport of Organic Anions and Cations in the Murine Mesonephros"
The mesonephros of mammals is a transient renal structure that contributes to various aspects of mammalian fetal development including the male reproductive system, hematopoietic stem cells and vascular endothelial cells. ... -
Morphometric data for Edinburgh_NIH10 dataset - all package runs
This data consists of morphometric measurements for the 10 subjects of the Edinburgh_NIH10 dataset (https://doi.org/10.7488/ds/2239) as well as Matlab code written to derive some statistics for these measurements. The ...
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