Quantitative Trait Locus (QTL) Identification
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The aims of this work are (i) to genetically map and identify quantitative trait loci (QTL) concerned with common human disorders; (ii) to characterise the genetic architecture of complex traits; (iii) to evaluate the use of genetic markers in trait prediction and treatment.
Items in this Collection
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Insights into the genetic basis of retinal detachment
Dataset of genome-wide association meta-analysis summary statistics associated with the publication “Insights into the genetic basis of retinal detachment” available as a preprint at BiorXiv: doi: https://doi.org/10.1101/581165. ... -
Dataset 2 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants"
The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across ... -
GWAS summary statistics for UPLC IgG N-glycosylation traits
The majority of proteins undergo post-translational glycosylation, in which complex carbohydrates are attached to the surface of proteins. However, when studying glycoproteins, the glycan component is often neglected. ... -
Dataset concerning the manuscript "Rare variants implicate ENPP6 as a regulator of reduced visceral adiposity"
The Orkney Complex Disease Study (ORCADES) is a family-based population cohort with DNA, biological samples, and a wide range of clinical data from ~2,000 adult volunteers from the Orkney Islands. Genotype data is also ... -
Central cornea thickness Genome Wide Association Meta Analyses - Summary statistics
Results from the meta-analyses of genome-wide association studies for central cornea thickness in human. Corneal thinning is a common feature of rare Mendelian connective tissue disorders, such as Ehlers-Danlos syndrome ... -
GWAS summary statistics for uric acid in GS:SFHS
The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across ... -
Summary GWAS data for morning plasma cortisol from the Cortisol Network (CORNET) Consortium 2014 (n=12,597)
Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of ... -
Dataset 1 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants"
The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across ... -
SUPERSEDED - Dataset 2 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants"
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2602 ## The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological ... -
Dataset pertaining to the publication “Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults.”
The majority of human proteins are post-translationally modified by covalent addition of one or more complex oligosaccharides (glycans). Alterations in glycosylation processing are associated with numerous diseases and ... -
Genome-wide p-values of nine multivariate IgG glycan GWAS
Whole-genome multivariate association results for nine groups of IgG N-glycosylation phenotypes. For the detailed definition of the glycan groups, please refer to Shen et al. (2017) Nature Communications: "Multivariate ... -
Family Genotype and Phenotype Data
The data forms part of the Resource pack Human genetic variation and disease, which is a real data resource to allow students to explore genetic and phenotypic data as part of their Scottish Qualifications Authority Nat5 ... -
Dataset pertaining to the publication “Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers”
Dataset pertaining to the publication “Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers”. The files are comma separated and contain genome ...
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