• Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers 

      Young, Robert; Taylor, Martin
      Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as ...
    • GenomeArtiFinder variant include list 

      Luft, Juliet; Taylor, Martin
      Background: The loss of genetic diversity in segments over a genome (loss-of-heterozygosity, LOH) is a common occurrence in many types of cancer. By analysing patterns of preferential allelic retention during LOH in ...
    • Lagging strand replication shapes the mutational landscape of the genome 

      Taylor, Martin; Kemp, Harriet; Marion de Procé, Sophie; Reijns, Martin; Ding, James; Jackson, Andrew
      The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends ...
    • Pervasive lesion segregation shapes cancer genome evolution 

      Aitken, Sarah; Anderson, Craig; Frances, Connor; Rayner, Tim; Lukk, Margus; Feng, Christine; Semple, Colin; Lopez-Bigas, Nuria; Flicek, Paul; Odom, Duncan; Taylor, Martin
      Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, ...