The MRC Human Genetics Unit is at the forefront of research into human genetics. Its role is to advance the understanding of genetic factors implicated in human disease and normal and abnormal development and physiology. It is situated at the Western General Hospital campus in Edinburgh.

www.hgu.mrc.ac.uk

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  • Supplementary files for study on modeling DSB with random forests 

    Ballinger, Tracy
    Structural variants (SVs) are known to play important roles in a variety of cancers, but their origins and functional consequences are still poorly understood. The nonrandom distributions of these variants across tumour ...
  • Supplementary Data to "Ligand binding site structure influences the evolution of protein complex function and topology" by G. Abrusan and J.A. Marsh 

    Abrusan, Gyorgy; Marsh, Joseph
    It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding ...
  • Dataset concerning the manuscript "Rare variants implicate ENPP6 as a regulator of reduced visceral adiposity" 

    Schraut, Katharina; Wilson, James F
    The Orkney Complex Disease Study (ORCADES) is a family-based population cohort with DNA, biological samples, and a wide range of clinical data from ~2,000 adult volunteers from the Orkney Islands. Genotype data is also ...
  • Central cornea thickness Genome Wide Association Meta Analyses - Summary statistics 

    Iglesias, Adriana I.; Mishra, Aniket; Vitart, Veronique; van Duijn, Cornelia M.; MacGregor, Stuart; on behalf of the "International Glaucoma Genetics Consortium"
    Results from the meta-analyses of genome-wide association studies for central cornea thickness in human. Corneal thinning is a common feature of rare Mendelian connective tissue disorders, such as Ehlers-Danlos syndrome ...
  • Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers 

    Young, Robert; Taylor, Martin
    Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as ...
  • Code and datasets for structural analyses in Natan et al, "Assembly in the translation milieu imposes evolutionary constraints on homomeric proteins" 

    Marsh, Joseph
    This contains datasets and Perl scripts needed to reproduce the figures in Natan et al "Assembly in the translation milieu imposes evolutionary constraints on homomeric proteins". Specifically, it can be used to calculate ...
  • 3D mouse embryo model: EMA81, Stage TS23, Age E15.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA80, Stage TS23, Age E15.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA82, Stage TS23, Age E15.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA79, Stage TS22, Age E14.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA113, Stage TS24, Age E16.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse forelimb model: EMA108, Stage TS23, Age E14.5 

    Delaurier, April; Mohun, Tim; Logan, Malcolm; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA53, Stage TS17, Age E10.5 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA77, Stage TS20, Age E12.0 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA116, Stage TS25, Age E17.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA112, Stage TS24, Age E16.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA68, Stage TS19, Age E11.5 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse kidney model: EMA105, Stage TS23, Age E15.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA106, Stage TS23, Age E14.5 

    Mohun, Tim; Armit, Chris; Burton, Nick; Hill, Bill; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...
  • 3D mouse embryo model: EMA78, Stage TS21, Age E13.0 (est) 

    Graham, Elizabeth; Moss, Julie; Richardson, Lorna; Brune, Renske; Armit, Chris; Burton, Nick; Hill, Bill; Davidson, Duncan; Baldock, Richard
    The eMouseAtlas team have generated a series of 3D images to capture mouse embryo development and to use as a spatial framework for gene-expression and other spatially organised data. The resource is published and available ...

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