Show simple item record

Depositordc.contributorMcAllister, David
Funderdc.contributor.otherScottish Governmenten_UK
Spatial Coveragedc.coverage.spatialCentral Scotlanden_UK
Spatial Coveragedc.coverage.spatialLothianen_UK
Spatial Coveragedc.coverage.spatialGlasgowen_UK
Spatial Coveragedc.coverage.spatialGreater Glasgow and Clydeen_UK
Spatial Coveragedc.coverage.spatialDundeeen_UK
Spatial Coveragedc.coverage.spatialTaysideen_UK
Spatial Coveragedc.coverage.spatialScotlanden_UK
Spatial Coveragedc.coverage.spatialUKen
Spatial Coveragedc.coverage.spatialUNITED KINGDOMen
Time Perioddc.coverage.temporalstart=2004-01-01; end=2011-11-30; scheme=W3C-DTFen
Data Creatordc.creatorMcAllister, David
Date Accessioneddc.date.accessioned2014-08-11T09:57:17Z
Date Availabledc.date.available2014-08-11T09:57:17Z
Date Issueddc.date.issued2014-08-11
Citationdc.identifier.citationMcAllister, David. (2014). Stress hyperglycaemia in hospitalised patients and their 3-year risk of diabetes: A Scottish Retrospective cohort study, 2004-2011 [text]. University of Edinburgh. Centre for Population Health Sciences. https://doi.org/10.7488/ds/70.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/611
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/70
Dataset Description (abstract)dc.description.abstractBackground: Hyperglycaemia during hospital admission is common in patients who are not known to have diabetes and is associated with adverse outcomes. The risk of subsequently developing type 2 diabetes, however, is not known. We linked a national database of hospital admissions with a national register of diabetes to describe the association between admission glucose and the risk of subsequently developing type 2 diabetes. Methods and Findings: In a retrospective cohort study, patients aged 30 years or older with an emergency admission to hospital between 2004 and 2008 were included. Prevalent and incident diabetes were identified through the Scottish Care Information (SCI)-Diabetes Collaboration national registry. Patients diagnosed prior to or up to 30 days after hospitalisation were defined as prevalent diabetes and were excluded. The predicted risk of developing incident type 2 diabetes during the 3 years following hospital discharge by admission glucose, age, and sex was obtained from logistic regression models. We performed separate analyses for patients aged 40 and older, and patients aged 30 to 39 years. Glucose was measured in 86,634 (71.0%) patients aged 40 and older on admission to hospital. The 3-year risk of developing type 2 diabetes was 2.3% (1,952/86,512) overall, was ,1% for a glucose #5 mmol/l, and increased to approximately 15% at 15 mmol/l. The risks at 7 mmol/l and 11.1 mmol/l were 2.6% (95% CI 2.5–2.7) and 9.9% (95% CI 9.2–10.6), respectively, with one in four (21,828/86,512) and one in 40 (1,798/86,512) patients having glucose levels above each of these cut-points. For patients aged 30–39, the risks at 7 mmol/l and 11.1 mmol/l were 1.0% (95% CI 0.8–1.3) and 7.8% (95% CI 5.7–10.7), respectively, with one in eight (1,588/11,875) and one in 100 (120/11,875) having glucose levels above each of these cut-points. The risk of diabetes was also associated with age, sex, and socio-economic deprivation, but not with specialty (medical versus surgical), raised white cell count, or co-morbidity. Similar results were obtained for pre-specified sub-groups admitted with myocardial infarction, chronic obstructive pulmonary disease, and stroke. There were 25,193 deaths (85.8 per 1,000 person-years) over 297,122 person-years, of which 2,406 (8.1 per 1,000 person-years) were attributed to vascular disease. Patients with glucose levels of 11.1 to 15 mmol/l and .15 mmol/l had higher mortality than patients with a glucose of ,6.1 mmol/l (hazard ratio 1.54; 95% CI 1.42–1.68 and 2.50; 95% CI 2.14–2.95, respectively) in models adjusting for age and sex. Limitations of our study include that we did not have data on ethnicity or body mass index, which may have improved prediction and the results have not been validated in non-white populations or populations outside of Scotland. Conclusion: Plasma glucose measured during an emergency hospital admission predicts subsequent risk of developing type 2 diabetes. Mortality was also 1.5-fold higher in patients with elevated glucose levels. Our findings can be used to inform patients of their long-term risk of type 2 diabetes, and to target lifestyle advice to those patients at highest risk.en_UK
Dataset Description (TOC)dc.description.tableofcontentsThis item contains a readme text file (.txt), four text files with R and SQL code (.txt), and one rich text metadata file (.rtf).en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. Centre for Population Health Sciencesen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttp://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001708
Relation (Is Referenced By)dc.relation.isreferencedbyDOI: 10.1371/journal.pmed.1001708
Subjectdc.subjectstress hyperglycaemiaen_UK
Subjectdc.subjecthyperglycaemiaen_UK
Subjectdc.subjecthyperglycemiaen_UK
Subjectdc.subjectdiabetesen_UK
Subjectdc.subjectrisk predictionen_UK
Subjectdc.subjectroutine dataen_UK
Subjectdc.subjectemergency admissionsen_UK
Subjectdc.subjectrisk calculatoren_UK
Subject Classificationdc.subject.classificationMedicine and Dentistry::Clinical Medicineen_UK
Titledc.titleStress hyperglycaemia in hospitalised patients and their 3-year risk of diabetes: A Scottish Retrospective cohort studyen_UK
Typedc.typetexten_UK

Download All
zip file MD5 Checksum: 4a0260878fa8ff9f3abfcf1f47aafbd1

Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record