Organ Fibrosis and Regeneration
Organ fibrosis (scarring) is a major cause of morbidity and mortality worldwide, and as yet there are no effective anti-fibrotic treatments. Research groups at the Centre for Inflammation Research are interested in the cellular and molecular mechanisms that drive organ fibrosis, and also the molecular pathways which are responsible for efficient wound healing and healthy tissue regeneration following injury. By understanding more about how organs scar, heal and regenerate they hope to develop new treatments for patients with fibrotic diseases.
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We profile the transcriptomes of non-parenchymal cell types present in healthy and cirrhotic human liver. In particular, we uncover a novel scar-associated TREM2+CD9+ macrophage subpopulation, which expands in liver fibrosis, ...