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Depositordc.contributorVandrey, Brianna
Funderdc.contributor.otherBBSRC - Biotechnology and Biological Sciences Research Councilen_UK
Funderdc.contributor.otherCarnegie Trust for the Universities of Scotlanden_UK
Funderdc.contributor.otherThe Royal Society of Edinburghen_UK
Funderdc.contributor.otherWellcome Trusten_UK
Data Creatordc.creatorVandrey, Brianna
Data Creatordc.creatorGarden, Derek
Data Creatordc.creatorAmbrozova, Veronika
Data Creatordc.creatorMcClure, Christina
Data Creatordc.creatorNolan, Matthew
Data Creatordc.creatorAinge, James
Date Accessioneddc.date.accessioned2019-10-03T09:08:22Z
Date Availabledc.date.available2019-10-03T09:08:22Z
Citationdc.identifier.citationVandrey, Brianna; Garden, Derek; Ambrozova, Veronika; McClure, Christina; Nolan, Matthew; Ainge, James. (2019). Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory, [dataset]. University of Edinburgh. Centre for Discovery Brain Science. https://doi.org/10.7488/ds/2629.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/3425
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2629
Dataset Description (abstract)dc.description.abstractEpisodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents. The LEC is critical for integrating spatial and contextual information about objects. Further, LEC neurons encode objects in the environment, the locations where objects were previously experienced, and generate representations of time during the encoding and retrieval of episodes. However, it remains unclear how specific populations of cells within the LEC contribute to the integration of episodic memory components. Layer 2 (L2) of LEC manifests early pathology in Alzheimer’s Disease (AD) and related animal models. Projections to the hippocampus from L2 of LEC arise from fan cells in a superficial sub-layer (L2a) that are immunoreactive for reelin and project to the dentate gyrus. Here, we establish an approach for selectively targeting fan cells using Sim1:Cre mice. Whereas complete lesions of the LEC were previously found to abolish associative recognition memory, we report that after selective suppression of synaptic output from fan cells mice can discriminate novel object-context configurations but are impaired in recognition of novel object-place-context associations. Our experiments suggest that memory functions are segregated between distinct LEC networks.en_UK
Dataset Description (TOC)dc.description.tableofcontentsSupplemental Data: raw data for object recognition behaviouren_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. Centre for Discovery Brain Scienceen_UK
Relation (Is Version Of)dc.relation.isversionofhttps://www.biorxiv.org/content/10.1101/543777v2.supplementary-materialen_UK
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectEpisodic memoryen_UK
Subjectdc.subjectEntorhinal cortexen_UK
Subjectdc.subjectLateral entorhinal cortexen_UK
Subjectdc.subjectHippocampusen_UK
Subjectdc.subjectObject recognitionen_UK
Subjectdc.subjectAnimal behaviouren_UK
Subject Classificationdc.subject.classificationBiological Sciencesen_UK
Titledc.titleFan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memoryen_UK
Typedc.typedataseten_UK

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    Data from the lab of Prof Matt Nolan

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