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Depositordc.contributorO'Donnell, Aidan
Funderdc.contributor.otherThe Royal Societyen_UK
Funderdc.contributor.otherWellcome Trusten_UK
Funderdc.contributor.otherHuman Frontiers Science Program (HFSP)en_UK
Data Creatordc.creatorO'Donnell, Aidan
Data Creatordc.creatorPrior, KF
Data Creatordc.creatorReece, Sarah E
Date Accessioneddc.date.accessioned2019-09-20T11:01:08Z
Date Availabledc.date.available2019-12-01T05:15:21Z
Citationdc.identifier.citationO'Donnell, Aidan; Prior, KF; Reece, Sarah E. (2019). Host circadian clocks do not set the schedule for the within-host replication of malaria parasites, [dataset]. University of Edinburgh. School of Biological Sciences. https://doi.org/10.7488/ds/2622.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/3418
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2622
Dataset Description (abstract)dc.description.abstractCircadian clocks coordinate organisms' activities with daily cycles in their environment. Parasites are subject to daily rhythms in the within-host environment, resulting from clock-control of host activities, including immune responses. Parasites also exhibit rhythms in their activities: the timing of within-host replication by malaria parasites is coordinated to host feeding rhythms. Precisely which host feeding-related rhythm(s) parasites align with and how this is achieved are unknown. Understanding rhythmic replication in malaria parasites matters because it underpins disease symptoms and fuels transmission investment. We test if rhythmicity in parasite replication is coordinated with the host's feeding-related rhythms and/or rhythms driven by the host's canonical circadian clock. We find that parasite rhythms coordinate with the time of day that hosts feed in both wild-type and clock-mutant hosts, whereas parasite rhythms become dampened in clock-mutant hosts that eat continuously. Our results hold whether infections are initiated with synchronous or with desynchronized parasites. We conclude that malaria parasite replication is coordinated to rhythmic host processes that are independent of the core-clock proteins PERIOD 1 and 2; most likely, a periodic nutrient made available when the host digests food. Thus, novel interventions could disrupt parasite rhythms to reduce their fitness, without interference by host clock-controlled homeostasis.en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. School of Biological Sciencesen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttps://doi.org/10.1098/rspb.2020.0347en_UK
Relation (Is Referenced By)dc.relation.isreferencedbyA.J. O’Donnell, K.F. Prior, S.E. Reece (2020). "Host circadian clocks do not set the schedule for the within-host replication of malaria parasites" Proceedings of the Royal Society B https://doi.org/10.1098/rspb.2020.0347
Relation (Is Referenced By)dc.relation.isreferencedbyhttps://www.biorxiv.org/content/10.1101/777011v2
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectPlasmodiumen_UK
Subjectdc.subjectTTFLen_UK
Subjectdc.subjectintraerythrocytic development cycleen_UK
Subjectdc.subjectperiodicityen_UK
Subjectdc.subjectcircadian rhythmen_UK
Subjectdc.subjectclock mutanten_UK
Subject Classificationdc.subject.classificationBiological Sciences::Biologyen_UK
Titledc.titleHost circadian clocks do not set the schedule for the within-host replication of malaria parasitesen_UK
Typedc.typedataseten_UK

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