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Depositordc.contributorO'Donnell, Aidan
Funderdc.contributor.otherThe Royal Societyen_UK
Funderdc.contributor.otherWellcome Trusten_UK
Funderdc.contributor.otherHuman Frontiers Science Program (HFSP)en_UK
Data Creatordc.creatorO'Donnell, Aidan
Data Creatordc.creatorPrior, KF
Data Creatordc.creatorReece, Sarah E
Date Accessioneddc.date.accessioned2019-09-20T11:01:08Z
Date Availabledc.date.available2019-12-01T05:15:21Z
Citationdc.identifier.citationO'Donnell, Aidan; Prior, KF; Reece, Sarah E. (2019). Host circadian clocks do not set the schedule for the within-host replication of malaria parasites, [dataset]. University of Edinburgh. School of Biological Sciences. https://doi.org/10.7488/ds/2622.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/3418
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2622
Dataset Description (abstract)dc.description.abstractCircadian clocks coordinate organisms’ activities with daily cycles in their environment. Parasites are subject to daily rhythms in the within-host environment, resulting from clock-control of host behaviours and physiologies, including immune responses. Parasites also exhibit rhythms in within-host activities; the timing of host feeding sets the timing of the within-host replication of malaria parasites. Why host feeding matters to parasites and how coordination with feeding is achieved are unknown. Determining whether parasites coordinate with clock-driven food-related rhythms of their hosts matters because rhythmic replication underpins disease symptoms and fuels transmission. We find that parasite rhythms became coordinated with the time of day that hosts feed in both wild type and clock-mutant mice, whereas parasite rhythmicity was lost in clock-mutant mice that fed continuously. These patterns occurred regardless of whether infections were initiated with synchronous or with desynchronised parasites. Malaria parasite rhythms are not driven by canonical clock-controlled host rhythms. Instead, we propose parasites coordinate with a temporally-restricted nutrient that becomes available through host digestion or are influenced by a separate clock-independent host process that directly responds to feeding. Thus, interventions could disrupt parasite rhythms to reduce their fitness, without interference by host clock-controlled-homeostasis.en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. School of Biological Sciencesen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttps://www.biorxiv.org/content/10.1101/777011v2en_UK
Relation (Is Referenced By)dc.relation.isreferencedbyA.J. O’Donnell, K.F. Prior, S.E. Reece (2019). Host circadian clocks do not set the schedule for the within-host replication of malaria parasites (submitted)
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectPlasmodiumen_UK
Subjectdc.subjectTTFLen_UK
Subjectdc.subjectintraerythrocytic development cycleen_UK
Subjectdc.subjectperiodicityen_UK
Subjectdc.subjectcircadian rhythmen_UK
Subjectdc.subjectclock mutanten_UK
Subject Classificationdc.subject.classificationBiological Sciences::Biologyen_UK
Titledc.titleHost circadian clocks do not set the schedule for the within-host replication of malaria parasitesen_UK
Typedc.typedataseten_UK

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