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Depositordc.contributorShi, Ting
Funderdc.contributor.otherEuropean Commissionen_UK
Spatial Coveragedc.coverage.spatialGlobalen_UK
Time Perioddc.coverage.temporalstart=1996-01; end=2018-04; scheme=W3C-DTFen
Data Creatordc.creatorShi, Ting
Date Accessioneddc.date.accessioned2019-03-29T10:51:44Z
Date Availabledc.date.available2019-04-01T04:15:07Z
Citationdc.identifier.citationShi, Ting. (2019). Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 2015: A systematic review and meta-analysis, 1996-2018 [dataset]. University of Edinburgh. https://doi.org/10.7488/ds/2519.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/3286
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2519
Dataset Description (abstract)dc.description.abstractRespiratory syncytial virus-associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years. We aimed to identify all studies worldwide investigating the disease burden of RSV-ARI in this population. We estimated the community incidence, hospitalization rate, and in-hospital case-fatality ratio (hCFR) of RSV-ARI in older adults, stratified by industrialized and developing regions, using data from a systematic review of studies published between January 1996 and April 2018 and 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burdens in older adults with RSV-ARI in the community and in hospitals for that year. We estimated the number of in-hospital deaths due to RSV-ARI by combining hCFR data with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5 million episodes (95% confidence interval [CI], .3 million-6.9 million) of RSV-ARI in older adults in industrialized countries (data for developing countries were missing), and of these, approximately 14.5% (214 000 episodes; 95% CI, 100 000-459 000) were admitted to hospitals. The global number of hospital admissions for RSV-ARI in older adults was estimated at 336 000 hospitalizations (uncertainty range [UR], 186 000-614 000). We further estimated about 14 000 in-hospital deaths (UR, 5000-50 000) related to RSV-ARI globally. The hospital admission rate and hCFR were higher for those aged ≥65 years than for those aged 50-64 years. The disease burden of RSV-ARI among older adults is substantial, with limited data from developing countries. Appropriate prevention and management strategies are needed to reduce this burden.en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburghen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttps://www.ncbi.nlm.nih.gov/pubmed/30880339en_UK
Relation (Is Referenced By)dc.relation.isreferencedbyTing Shi, A. Denouel, A.K. Tietjen, I. Campbell, E. Moran, X. Li, H. Campbell, C. Demont, B.O. Nyawanda, H.Y. Chu, S.K. Stoszek, A. Krishnan, P. Openshaw, A.R. Falsey, Harish Nair; RESCEU Investigators . Global Disease Burden Estimates of Respiratory Syncytial Virus-Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis. J Infect Dis. 2019 Mar 18. pii: jiz059. doi: 10.1093/infdis/jiz059. [Epub ahead of print]en_UK
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectRSVen_UK
Subject Classificationdc.subject.classificationMedicine and Dentistryen_UK
Titledc.titleGlobal disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 2015: A systematic review and meta-analysisen_UK
Typedc.typedataseten_UK

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