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Depositordc.contributorWishart, Thomas
Funderdc.contributor.otherBBSRC - Biotechnology and Biological Sciences Research Councilen_UK
Data Creatordc.creatorKing, Declan
Date Accessioneddc.date.accessioned2018-08-27T10:10:42Z
Citationdc.identifier.citationKing, Declan. (2019). Investigating early cellular and molecular responses to misfolded protein, [dataset]. University of Edinburgh. https://doi.org/10.7488/ds/2425.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/3168
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2425
Dataset Description (abstract)dc.description.abstractPMDs such as AD, PD, HD and TSE are associated with the accumulation of abnormally folded proteins. However, the mechanisms involving seeding, processing and degradation of these rogue proteins are poorly understood. In this project, the response of primary hippocampal cultures to fibril challenge was investigated on a transcriptome level. This provided insights into molecular mechanisms associated with misfolded protein handling using cultures that either support misfolded protein generation (101LL) or that curtail its production (WT). Initial baseline transcriptome profiles were generated by microarray analysis then a more comprehensive analysis using RNA-sequencing (RNA-seq) for pre and post-fibril challenge transcriptome analysis was carried out.en_UK
Dataset Description (TOC)dc.description.tableofcontentsSee DataShareInfo.txten_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburghen_UK
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectCell Cultureen_UK
Subjectdc.subjectRNAen_UK
Subjectdc.subjectRNASeqen_UK
Subjectdc.subjectProtein misfoldingen_UK
Subjectdc.subjectclusteringen_UK
Subject Classificationdc.subject.classificationBiological Sciencesen_UK
Titledc.titleInvestigating early cellular and molecular responses to misfolded proteinen_UK
Typedc.typedataseten_UK
Embargo Datedc.date.embargo2020-12-01


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