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Depositordc.contributorHoward, David
Funderdc.contributor.otherWellcome Trusten_UK
Spatial Coveragedc.coverage.spatialUKen_UK
Spatial Coveragedc.coverage.spatialUKen
Spatial Coveragedc.coverage.spatialUNITED KINGDOMen
Data Creatordc.creatorHoward, David
Data Creatordc.creatorAdams, Mark
Data Creatordc.creatorShirali, Masoud
Data Creatordc.creatorClarke, Toni-Kim
Data Creatordc.creatorMarioni, Riccardo
Data Creatordc.creatorDavies, Gail
Data Creatordc.creatorColeman, Jonathan
Data Creatordc.creatorAlloza, Clara
Data Creatordc.creatorShen, Xueyi
Data Creatordc.creatorBarbu, Miruna
Data Creatordc.creatorWigmore, Eleanor
Data Creatordc.creatorGibson, Jude
Data Creatordc.creator23andMe Research Team
Data Creatordc.creatorHagenaars, Saskia
Data Creatordc.creatorLewis, Cathryn
Data Creatordc.creatorWard, Joey
Data Creatordc.creatorSmith, Daniel
Data Creatordc.creatorSullivan, Patrick
Data Creatordc.creatorHaley, Chris
Data Creatordc.creatorBreen, Gerome
Data Creatordc.creatorDeary, Ian
Data Creatordc.creatorMcIntosh, Andrew
Citationdc.identifier.citationHoward, David; Adams, Mark; Shirali, Masoud; Clarke, Toni-Kim; Marioni, Riccardo; Davies, Gail; Coleman, Jonathan; Alloza, Clara; Shen, Xueyi; Barbu, Miruna; Wigmore, Eleanor; Gibson, Jude; 23andMe Research Team; Hagenaars, Saskia; Lewis, Cathryn; Ward, Joey; Smith, Daniel; Sullivan, Patrick; Haley, Chris; Breen, Gerome; Deary, Ian; McIntosh, Andrew. (2018). Summary statistics for three depression phenotypes in UK Biobank, [dataset]. University of Edinburgh.
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Persistent Identifierdc.identifier.uri
Dataset Description (abstract)dc.description.abstractDepression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10-8) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in excitatory neurotransmission, mechanosensory behavior, postsynapse, neuron spine, and dendrite functions. Our findings suggest that broad depression is the most tractable UK Biobank phenotype for discovering genes and gene-sets that further our understanding of the biological pathways underlying depression.en_UK
Publisherdc.publisherUniversity of Edinburghen_UK
Relation (Is Referenced By)dc.relation.isreferencedby
Relation (Is Referenced By)dc.relation.isreferencedbyHoward et al. (2018) Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. Nature Communications, 9:1470. doi:10.1038/s41467-018-03819-3en_UK
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectMajor Depressive Disorderen_UK
Subjectdc.subjectUK Biobanken_UK
Subjectdc.subjectGenome-wide association studyen_UK
Subject Classificationdc.subject.classificationBiological Sciences::Geneticsen_UK
Titledc.titleSummary statistics for three depression phenotypes in UK Biobanken_UK

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