Synthesis and chemical biology.

Items in this Collection

  • Imaging Drug Uptake by Bioorthogonal Stimulated Raman Scattering Microscopy 

    Tipping, William J; Lee, Martin; Serrels, Alan; Brunton, Valerie G; Hulme, Alison N
    Stimulated Raman scattering (SRS) microscopy in tandem with bioorthogonal Raman labelling strategies is set to revolutionise the direct visualisation of intracellular drug uptake. Rational evaluation of a series of ...
  • Chloromethyl-triazole: A new motif for site-selective pseudo-acylation of proteins 

    Brewster, Richard C; Gavins, Georgina C; Günthardt, Barbara; Farr, Sarah; Webb, Kimberly M; Voigt, Philipp; Hulme, Alison N
    Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide ...