Clinical depression is a chronic worldwide health problem affecting millions of people and approximately 13 per cent of the UK population. Researchers say that although it is a chronic and recurrent problem for many sufferers, little is known about what makes people vulnerable or resilient to the condition. Lead researcher, Andrew McIntosh, Professor of Biological Psychiatry at the University of Edinburgh, said: "For many people the symptom of low mood is the most understandable of reactions to loss or stress, yet we remain ignorant of its causes and mechanisms. This means that progress in discovering new and more effective treatments is slow. This Wellcome Trust grant will enable us to make significant progress with this common and disabling condition". The study - known as Stratifying Resilience and Depression Longitudinally (STRADL) - involves researchers from the University of Edinburgh's Division of Psychiatry, Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), Institute for Genetics and Molecular Medicine (IGMM) and brain imaging facilities in Edinburgh and at the University of Aberdeen.

Items in this Collection

  • Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals 

    Howard, David; Adams, Mark; Clarke, Toni-Kim; Hafferty, Jonathan; Gibson, Jude; Shirali, Masoud; Coleman, Jonathan; Ward, Joey; Wigmore, Eleanor; Alloza, Clara; Shen, Xueyi; Barbu, Miruna; Xu, Eileen; Whalley, Heather; Marioni, Riccardo; Porteous, David; Davies, Gail; Deary, Ian; Hemani, Gibran; Tian, Chao; Hinds, David; 23andMe Research Team; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Trzaskowshi, Maciej; Byrne, Enda; Ripke, Stephan; Smith, Daniel; Sullivan, Patrick; Wray, Naomi; Breen, Gerome; Lewis, Cathryn; McIntosh, Andrew
    Major depression is a debilitating psychiatric illness that is typically associated with low mood, anhedonia and a range of comorbidities. Depression has a heritable component that has remained difficult to elucidate with ...
  • Summary statistics for three depression phenotypes in UK Biobank 

    Howard, David; Adams, Mark; Shirali, Masoud; Clarke, Toni-Kim; Marioni, Riccardo; Davies, Gail; Coleman, Jonathan; Alloza, Clara; Shen, Xueyi; Barbu, Miruna; Wigmore, Eleanor; Gibson, Jude; 23andMe Research Team; Hagenaars, Saskia; Lewis, Cathryn; Ward, Joey; Smith, Daniel; Sullivan, Patrick; Haley, Chris; Breen, Gerome; Deary, Ian; McIntosh, Andrew
    Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the ...
  • SUPERSEDED - Summary statistics for three depression phenotypes in UK Biobank 

    Howard, David; Adams, Mark; Shirali, Masoud; Clarke, Toni-Kim; Marioni, Riccardo; Davies, Gail; Coleman, Jonathan; Alloza, Clara; Shen, Xueyi; Barbu, Miruna; Wigmore, Eleanor; Gibson, Jude; 23andMe Research Team; Hagenaars, Saskia; Lewis, Cathryn; Ward, Joey; Smith, Daniel; Sullivan, Patrick; Haley, Chris; Breen, Gerome; Deary, Ian; McIntosh, Andrew
    ## This item has been replaced by the one which can be found at http://dx.doi.org/10.7488/ds/2350 ## Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified ...
  • SUPERSEDED - Summary statistics for three depression phenotypes in UK Biobank 

    Howard, David
    ## This item has been replaced by the one which can be found at http://dx.doi.org/10.7488/ds/2314 ## Depression is a polygenic trait that causes extensive periods of disability and increases the risk of suicide, a ...