Clinical depression is a chronic worldwide health problem affecting millions of people and approximately 13 per cent of the UK population. Researchers say that although it is a chronic and recurrent problem for many sufferers, little is known about what makes people vulnerable or resilient to the condition. Lead researcher, Andrew McIntosh, Professor of Biological Psychiatry at the University of Edinburgh, said: "For many people the symptom of low mood is the most understandable of reactions to loss or stress, yet we remain ignorant of its causes and mechanisms. This means that progress in discovering new and more effective treatments is slow. This Wellcome Trust grant will enable us to make significant progress with this common and disabling condition". The study - known as Stratifying Resilience and Depression Longitudinally (STRADL) - involves researchers from the University of Edinburgh's Division of Psychiatry, Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), Institute for Genetics and Molecular Medicine (IGMM) and brain imaging facilities in Edinburgh and at the University of Aberdeen.

Items in this Collection

  • Summary statistics for three depression phenotypes in UK Biobank 

    Howard, David; Adams, Mark; Shirali, Masoud; Clarke, Toni-Kim; Marioni, Riccardo; Davies, Gail; Coleman, Jonathan; Alloza, Clara; Shen, Xueyi; Barbu, Miruna; Wigmore, Eleanor; Gibson, Jude; 23andMe Research Team; Hagenaars, Saskia; Lewis, Cathryn; Ward, Joey; Smith, Daniel; Sullivan, Patrick; Haley, Chris; Breen, Gerome; Deary, Ian; McIntosh, Andrew
    We are working on adding additional information to this data. In the meantime please use the data available here: http://dx.doi.org/10.7488/ds/2314. Depression is a polygenic trait that causes extensive periods of disability. ...
  • Summary statistics for three depression phenotypes in UK Biobank 

    Howard, David; Adams, Mark; Shirali, Masoud; Clarke, Toni-Kim; Marioni, Riccardo; Davies, Gail; Coleman, Jonathan; Alloza, Clara; Shen, Xueyi; Barbu, Miruna; Wigmore, Eleanor; Gibson, Jude; 23andMe Research Team; Hagenaars, Saskia; Lewis, Cathryn; Ward, Joey; Smith, Daniel; Sullivan, Patrick; Haley, Chris; Breen, Gerome; Deary, Ian; McIntosh, Andrew
    Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the ...
  • SUPERSEDED - Summary statistics for three depression phenotypes in UK Biobank 

    Howard, David
    ## This item has been replaced by the one which can be found at http://dx.doi.org/10.7488/ds/2314 ## Depression is a polygenic trait that causes extensive periods of disability and increases the risk of suicide, a ...