Now showing items 1-11 of 11
Open prediction of polysaccharide utilisation loci (PUL) in 5414 public Bacteroidetes genomes using PULpy
Polysaccharide utilisation loci (PUL) are regions within the genomes of Bacteroidetes that encode all the necessary machinery for the cleavage of particular carbohydrates. Prediction of PUL from genomic data alone involves ...
Proteomic profiling of primate synapses during normal healthy ageing
Normal mammalian brain ageing is characterised by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous ...
Proteomic analysis for peripherally accessible biomarkers in Neuronal Ceroid Lipofuscinosis (NCL)
iTRAQ and Label free Proteomic data generated from Skeletal muscle of CLN3 and PPT1 murine models of Batten disease.
Single cell transcriptional profiling of rat embryonic stem cells defined by Rex1-EGFP reporter expression
Rat embryonic stem cells exhibit basal levels of spontaneous differentiation in 2i+LIF (2iL) culture. Expression of a stem cell specific Rex1-EGFP knock-in reporter transgene in rat ESCs was used to isolate functionally ...
TMT generated proteomic identification and quantification of muscle and NMJ enriched fractions in mice and humans
The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neurons to skeletal muscle to generate movement. It is also an experimentally-accessible model synapse routinely studied ...
"Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility"
Data supporting Donaldson et al "Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility" (In Submission).
Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia
Bash scripts, R scripts, rehh output data.
SUPERSEDED - Water buffalo and cattle XPEHH scores across breeds
## SUPERSEDED - This dataset has been replaced by the one which can be found at https://doi.org/10.7488/ds/2849 . ## This dataset consists of XP-EHH scores calculated using the hapbin software (https://github.com/evotools/hapbin) ...
lentiviral mediated apoE4 transduction in primary neuronal culture
To identify the molecular changes in signalling pathways triggered by altered apoE4 expression, we used lentiviral transduction to overexpress human apoE4 in 18-21 DIV primary hippocampal neurons. The molecular consequences ...
GenOMICC Covid-19 critical illness summary statistics non-European ancestries
Non-European ancestries GWAS summary statistics for Covid-19 critical illness from the GenOMICC study
Investigating early cellular and molecular responses to misfolded protein
PMDs such as AD, PD, HD and TSE are associated with the accumulation of abnormally folded proteins. However, the mechanisms involving seeding, processing and degradation of these rogue proteins are poorly understood. In ...