Wishart, Thomas. (2017). TMT generated proteomic identification and quantification of muscle and NMJ enriched fractions in mice and humans, [dataset]. http://dx.doi.org/10.7488/ds/2240.
The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neurons to skeletal muscle to generate movement. It is also an experimentally-accessible model synapse routinely studied in animal models to explore fundamental aspects of synaptic form and function.
This dataset comprises part of a wider study examining the composition and form of the neuromuscular junction (NMJ) in mice and humans. The data sets demonstrate differential expression of core synaptic proteins and molecular pathways at the human NMJ. This data as part of a larger study reveals human-specific cellular and molecular features of the NMJ that distinguish them from comparable synapses in other mammalian species.
Abbreviation: TMT – “Tandem Mass Tag multiplexing reagents” for labelling amine groups.