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Depositordc.contributorGrant, Seth
Funderdc.contributor.otherMRC - Medical Research Councilen_UK
Funderdc.contributor.otherEuropean Commissionen_UK
Funderdc.contributor.otherWellcome Trust
Spatial Coveragedc.coverage.spatialUKen
Spatial Coveragedc.coverage.spatialUNITED KINGDOMen
Time Perioddc.coverage.temporalstart=2013; end=2016; scheme=W3C-DTFen
Data Creatordc.creatorGrant, Seth
Data Creatordc.creatorRoy, Marcia
Data Creatordc.creatorSorokina, Oksana
Data Creatordc.creatorSkene, Nathan
Data Creatordc.creatorSimonnet, Clemence
Data Creatordc.creatorSmith, Colin
Data Creatordc.creatorArmstrong, J Douglas
Date Accessioneddc.date.accessioned2017-09-01T15:06:46Z
Date Availabledc.date.available2017-09-01T15:06:46Z
Citationdc.identifier.citationGrant, Seth; Roy, Marcia; Sorokina, Oksana; Skene, Nathan; Simonnet, Clemence; Smith, Colin; Armstrong, J. Douglas. (2017). Proteomic analysis of postsynaptic proteins in regions of the human neocortex, 2013-2016 [dataset]. University of Edinburgh. Centre for Clinical Brain Sciences. https://doi.org/10.7488/ds/2128.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/2811
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2128
Dataset Description (abstract)dc.description.abstractThe postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire and mutations disrupting their function cause >130 brain diseases. Here, we document the composition of postsynaptic proteomes in human neocortical regions and integrate it with genetic, functional and structural magnetic resonance imaging, positron emission tomography imaging, and behavioral data. Neocortical regions show signatures of expression of individual proteins, protein complexes, biochemical and metabolic pathways. The compositional signatures in brain regions involved with language, emotion and memory functions were characterized. Integrating large-scale GWAS with regional proteome data identifies the same cortical region for smoking behavior as found with fMRI data. The neocortical postsynaptic proteome data resource can be used to link genetics to brain imaging and behavior, and to study the role of postsynaptic proteins in localization of brain functions. This dataset replaces http://hdl.handle.net/10283/2362en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. Centre for Clinical Brain Sciencesen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttp://doi.org/10.1038/s41593-017-0025-9
Relation (Is Referenced By)dc.relation.isreferencedbyRoy, M, Sorokina, O, Skene, N, Simonnet, C, Mazzola, F, Zwart, R, Sher, E, Smith, C, Armstrong, JD & Grant, S 2017, 'Proteomic analysis of postsynaptic proteins in regions of the human neocortex' Nature Neuroscience. DOI: 10.1038/s41593-017-0025-9
Supersedesdc.relation.replaceshttp://hdl.handle.net/10283/2362en_UK
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectproteomeen_UK
Subjectdc.subjectbrainen_UK
Subjectdc.subjecthumanen_UK
Subjectdc.subjectsynapseen_UK
Subjectdc.subjectpostsynaptic densityen_UK
Subjectdc.subjectBrodmann areaen_UK
Subject Classificationdc.subject.classificationBiological Sciencesen_UK
Titledc.titleProteomic analysis of postsynaptic proteins in regions of the human neocortexen_UK
Typedc.typedataseten_UK

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