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Depositordc.contributorWilkinson, Samantha
Funderdc.contributor.otherBBSRC - Biotechnology and Biological Sciences Research Councilen_UK
Data Creatordc.creatorBishop, Steve
Data Creatordc.creatorAllen, Adrian
Data Creatordc.creatorMcBride, Stuart
Data Creatordc.creatorSkuce, Robin
Data Creatordc.creatorBermingham, Mairead
Data Creatordc.creatorWoolliams, John
Data Creatordc.creatorGlass, Liz
Data Creatordc.creatorWilkinson, Samantha
Date Accessioneddc.date.accessioned2017-06-27T10:21:55Z
Date Availabledc.date.available2017-06-27T10:21:55Z
Citationdc.identifier.citationBishop, Steve; Allen, Adrian; McBride, Stuart; Skuce, Robin; Bermingham, Mairead; Woolliams, John; Glass, Liz; Wilkinson, Samantha. (2017). Data from the study "Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows", [dataset]. University of Edinburgh. https://doi.org/10.7488/ds/2074.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/2743
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2074
Dataset Description (abstract)dc.description.abstractThis dataset derives form a study on the host genetic variation in resistance to bovine tuberculosis (bTB) in dairy cattle. It is well established that host genetic variation in resistance to bTB exists in dairy cattle. However, cattle diagnosed as infected with M. bovis display varying signs of pathology. The variation in host response to infection could represent a continuum since time of exposure or distinct outcomes due to differing pathogen handling. To investigate this 1966 Holstein-Friesian dairy cows were genotyped using the the BovineHD SNP chip. Three distinct phenotypes were defined in the study single intradermal cervical comparative tuberculin (SICCT) test positives with visible lesions (VLs), SICCT-positives with undetected visible lesions (NVLs) and matched controls SICCT-negative on multiple occasions. Up to 15 of the 29 chromosomes of the bovine genome were found to harbour heritable variation. By case phenotype, 4 of 5 chromosomes explaining heritable variation in the VLs were also found for NVLs, but an additional 10 chromosomes were unique to NVLs. Furthermore, five different genomic regions with heritable variation were found for the two case phenotypes. A genomic region of interest detected in NVLs, but not VLs, was on chromosome 23 located near the bovine leukocyte antigen (BoLA) class IIb region. BoLA is the bovine version of the Major Histocompatibility Complex, a family of genes which encode cell surface molecules involved in the immune system, playing an important role in disease resistance. The results suggest some differing underlying genetics governing observed versus non-observed pathology for bTB infected animals, supporting the notion of a bTB infection spectrum. The implications of complex genetic control of bTB susceptibility may need to be considered in disease control.en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburghen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttps://link.springer.com/article/10.1186/s12864-017-3836-xen_UK
Subjectdc.subjectbovine tuberculosisen_UK
Subjectdc.subjectdairy cattleen_UK
Subjectdc.subjectbovineHD SNP chipen_UK
Subjectdc.subjectgenetic variationen_UK
Subject Classificationdc.subject.classificationVeterinary Sciences Agriculture and related subjectsen_UK
Titledc.titleData from the study "Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows"en_UK
Typedc.typedataseten_UK

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