Show simple item record

Depositordc.contributorRoman Garcia, Susana
Funderdc.contributor.otherUniversity of Edinburghen_UK
Data Creatordc.creatorRoman Garcia, Susana
Data Creatordc.creatorStefan, Melanie
Citationdc.identifier.citationRoman Garcia, Susana; Stefan, Melanie. (2017). Computational modelling and simulation of the interaction between NMDA receptors and CaMKII in the postsynaptic neuron, [dataset]. University of Edinburgh,,, The National Center for Multiscale Modeling of Biological Systems (MMBioS).
Persistent Identifierdc.identifier.uri
Persistent Identifierdc.identifier.uri
Dataset Description (abstract)dc.description.abstract## SUPERSEDED - This item has been replaced by the one which can be found at . ## NMDAR and CaMKII interactions in the postsynaptic neuron play crucial roles that underlie our ability to learn and form memories. Their activity varies with time and space, and elucidating this matter is important for understanding how memory works. We develop a computer model that creates realistic 3D movements and reactions of molecules within a cell. It is an isolated model that enables us to look specifically at our molecules of interest, NMDARs and CaMKII. The report aims to answer three main questions which should address: the validity of our model against previous knowledge, the effects of sub-cellular localization on CaMKII and the effects on CaMKII by abolishing CaMKII/NMDAR binding. For the first question, we compared results with published literature. Secondly, counting boxes were added to the cell to assess if PSD regions were associated with higher molecule levels compared to cytosolic regions. Lastly, a mutant model was created to account for effects of CaMKII/NMDAR binding impairments. These experiments found that our model is consistent with what is known about sequence of molecule reactions and timeline of CaMKII activation. We could not conclude that space affects CaMKII activity as suggested, but we found that abolishing the interaction between NMDARs and CaMKII increased levels of free, phosphorylated CaMKII.en_UK
Publisherdc.publisherUniversity of Edinburgh. School of Biological Sciencesen_UK
Superseded Bydc.relation.isreplacedby
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Sourcedc.sourceWith thanks to colleagues from for assistance with technical matters.
Sourcedc.sourceWith thanks to colleagues from The National Center for Multiscale Modeling of Biological Systems (MMBioS) for assistance with technical matters.en
Subjectdc.subjectMolecular Biologyen_UK
Subjectdc.subjectComputer modellingen_UK
Subjectdc.subjectNMDAR and CaMKII interactionsen_UK
Subjectdc.subjectPostsynaptic neuron modelen_UK
Subject Classificationdc.subject.classificationBiological Sciencesen_UK
Titledc.title## SUPERSEDED ## Computational modelling and simulation of the interaction between NMDA receptors and CaMKII in the postsynaptic neuronen_UK

Download All
zip file MD5 Checksum: 38b529b671362d157296fddd5a2bb581

Files in this item


This item appears in the following Collection(s)

  • Stefan Lab
    The Stefan Lab is interested in the computational modelling of processes related to learning and memory across scales.

Show simple item record