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Depositordc.contributorMegia-Fernandez, Alicia
Funderdc.contributor.otherEPSRC - Engineering and Physical Sciences Research Councilen_UK
Funderdc.contributor.otherMRC - Medical Research Councilen_UK
Funderdc.contributor.otherEuropean Commissionen_UK
Spatial Coveragedc.coverage.spatialUKen
Spatial Coveragedc.coverage.spatialUNITED KINGDOMen
Data Creatordc.creatorMills, Bethany
Data Creatordc.creatorMegia-Fernandez, Alicia
Date Accessioneddc.date.accessioned2017-05-03T11:20:49Z
Date Availabledc.date.available2017-05-03T11:20:49Z
Citationdc.identifier.citationMills, Bethany; Megia-Fernandez, Alicia. (2017). Dataset for paper 'Highly Selective and Rapidly Activatable Fluorogenic Thrombin Sensors and Application in Human Lung Tissue', [dataset]. University of Edinburgh. School of Chemistry. https://doi.org/10.7488/ds/2006.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/2669
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2006
Dataset Description (abstract)dc.description.abstractDataset related to publication DOI: 10.1039/c7ob00663b. A library of FRET-based peptides were prepared and studied as Thrombin substrates. This identified probes that showed selective activation by Thrombin, low background signal, stability to Factor Xa, matrix metalloproteases, and primary human inflammatory cell lysates and supernatant. These were selected for further optimization, creating a second generation of fluorogenic probes with improved solubility and Plasmin resistance. The optimized probe detected Thrombin activity ex vivo in fibrotic human lung tissue.en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. School of Chemistryen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttp://pubs.rsc.org/en/content/articlelanding/2017/ob/c7ob00663b#!divAbstracten_UK
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectfluorogenic probesen_UK
Subjectdc.subjectThrombinen_UK
Subject Classificationdc.subject.classificationBiological Sciencesen_UK
Titledc.titleDataset for paper 'Highly Selective and Rapidly Activatable Fluorogenic Thrombin Sensors and Application in Human Lung Tissue'en_UK
Typedc.typedataseten_UK

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