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Depositordc.contributorDavies, Jamie
Funderdc.contributor.otherBBSRC - Biotechnology and Biological Sciences Research Councilen_UK
Funderdc.contributor.otherThe Anatomical Society of Great Britain and Ireland
Data Creatordc.creatorMartin, Kimberley Cordwint
Data Creatordc.creatorDavies, Jamie
Date Accessioneddc.date.accessioned2017-01-24T14:50:00Z
Date Availabledc.date.available2017-01-24T14:50:00Z
Citationdc.identifier.citationMartin, Kimberley Cordwint; Davies, Jamie. (2017). Data supporting Martin et al (2017) "Symmetry-breaking in branching epithelia...", [dataset]. University of Edinburgh. College of Medicine and Veterninary Medicine. Centre for Integrative Physiology. https://doi.org/10.7488/ds/1701.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/2348
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/1701
Dataset Description (abstract)dc.description.abstractThese are raw image datasets and analyses used in a J. Anat. paper (Martin et al., 2017) with the following abstract: Branching morphogenesis of epithelia involves division of cells into leader (tip) and follower (stalk) cells. Published work on cell lines in culture has suggested that symmetry breaking takes place via a secreted autocrine inhibitor of motility, the inhibitor accumulating more in concave regions of the culture boundary, slowing advance of cells there, and less in convex areas, allowing advance and a further exaggeration of the concave/ convex difference. Here we test this hypothesis using a 2D culture system that includes strong flow conditions to remove accumulating diffusible secretions. We find that, while motility does indeed follow boundary curvature in this system, flow makes no difference: this challenges the hypothesis of control by a diffusible secreted autocrine inhibitor. N.B. Data obtained by KC Martin under the direction of Prof Jamie Davies.en_UK
Dataset Description (TOC)dc.description.tableofcontentsThere is one overall data spreadsheet, and three zipped files containing raw images and analyses of them. The entire context if explained in Martin et al. (2017) Symmetry-breaking in branching epithelia: cells on micro-patterns under flow challenge the hypothesis of positive feedback by a secreted autocrine inhibitor of motility. J. Anat (in press)en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. College of Medicine and Veterninary Medicine. Centre for Integrative Physiologyen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttps://doi.org/10.1111/joa.12599en_UK
Relation (Is Referenced By)dc.relation.isreferencedbyMartin, K, Yuan, X, Stimac, G, Bannerman, K, Anderson, J, Roy, C, Glykofrydis, F, Yin, H & Davies, J 2017, 'Symmetry-­breaking in branching epithelia: cells on micro-patterns under flow challenge the hypothesis of positive feedback by a secreted autocrine inhibitor of motility.' Journal of Anatomy. DOI: 10.1111/joa.12599
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectCell Biologyen_UK
Subjectdc.subjectbranching morphogenesisen_UK
Subjectdc.subjectflowen_UK
Subjectdc.subjectdiffusible inhibitoren_UK
Subjectdc.subjectsymmetry-breakingen_UK
Subject Classificationdc.subject.classificationBiological Sciences::Developmental Biologyen_UK
Titledc.titleData supporting Martin et al (2017) "Symmetry-breaking in branching epithelia..."en_UK
Typedc.typedataseten_UK

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