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Using the pimeloyl-CoA synthetase adenylation fold to synthesise fatty acid thioesters
Biotin is an essential vitamin in plants and mammals functioning as the carbon dioxide carrier within central lipid metabolism. Bacterial pimeloyl-CoA synthetase (PCAS) acts as a highly specific substrate selection gate ...
Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45)
We use mass spectrometry analysis and molecular modelling to show the established antimicrobial inhibitor 4,5-dichloro-1,2-dithiol-3-one (HR45) acts by forming a covalent adduct with the target β-ketoacyl-ACP synthase III ...
The carbon chain-selective adenylation enzyme TamA: the missing link between fatty acid and pyrrole natural product biosynthesis
Data files of mass spectrometry (LC-MS) experiments in support of our publication. These .raw files require Mass Lynx Version 4.1 software to open.
Use of Isotopically Labelled Substrates Reveals Kinetic Differences Between Human and Bacterial Serine Palmitoyltransferase
Please see the associated journal publication for contextual information.