Now showing items 1-3 of 3
Using the pimeloyl-CoA synthetase adenylation fold to synthesise fatty acid thioesters
Biotin is an essential vitamin in plants and mammals functioning as the carbon dioxide carrier within central lipid metabolism. Bacterial pimeloyl-CoA synthetase (PCAS) acts as a highly specific substrate selection gate ...
Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45)
We use mass spectrometry analysis and molecular modelling to show the established antimicrobial inhibitor 4,5-dichloro-1,2-dithiol-3-one (HR45) acts by forming a covalent adduct with the target β-ketoacyl-ACP synthase III ...
The carbon chain-selective adenylation enzyme TamA: the missing link between fatty acid and pyrrole natural product biosynthesis
Data files of mass spectrometry (LC-MS) experiments in support of our publication. These .raw files require Mass Lynx Version 4.1 software to open.