Campopiano Research Group
Professor Dominic Campopiano's research group conducts research into industrial biocatalysis, including natural product biosynthesis, enzymology, protein structure, antibiotics, innate immunity enzyme inhibitors.
Items in this Collection
Non-invasive 19F NMR analysis of a protein-templated N- acylhydrazone dynamic combinatorial library. OBC 2018 Supplementary data to support the following publication (abstract): Dynamic combinatorial chemistry (DCC) is a powerful tool to identify ligands for biological targets. We used 19F NMR as an in situ, non-invasive technique ...
The carbon chain-selective adenylation enzyme TamA: the missing link between fatty acid and pyrrole natural product biosynthesis Data files of mass spectrometry (LC-MS) experiments in support of our publication. These .raw files require Mass Lynx Version 4.1 software to open.
Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45) We use mass spectrometry analysis and molecular modelling to show the established antimicrobial inhibitor 4,5-dichloro-1,2-dithiol-3-one (HR45) acts by forming a covalent adduct with the target β-ketoacyl-ACP synthase III ...
Biotin is an essential vitamin in plants and mammals functioning as the carbon dioxide carrier within central lipid metabolism. Bacterial pimeloyl-CoA synthetase (PCAS) acts as a highly specific substrate selection gate ...