Genome-wide association study summary statistics for antidepressant treatment resistance
Data from Wigmore et al "Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP". The Pharmacogenomics Journal 20, 329–341 (2020) DOI:10.1038/s41397-019-0067-3
This dataset consists of two sets of GWAS summary statistics:
- case-control analysis of treatment resistance phenotype in the Generation Scotland and GENDEP samples (inverse variance weighted meta-analysis). Cases = 358, Controls = 3855.
- quantitative stages of resistance phenotype in Generation Scotland. N = 3452.
File: TRD_meta.Wigmore2020.txt.gz
Description: Meta-analysis of Generation Scotland and GENDEP
Columns:
- CHR: chromosome
- SNP: marker RSID
- BP: base-pair position
- A1: effect allele
- A2: non-effect allele
- Freq1: average frequency of A1
- FreqSE: standard error of frequency
- logOR: effect of A1 as log Odds Ratio
- logOR_SE: standard error of the effect
- P: p-value
- Direction: direction of effect from each study (order: GENDEP, GenScot)
- HetISq, HetChiSq, HetDf, HetPVal: heterogeneity statistics
File: TRD_Stages.Wigmore2020.txt.gz
Description: Stage of resistance in Generation Scotland
Columns:
- CHR: chromsome
- SNP: marker RSID
- BP: base-pair position
- A1: effect allele
- A2: non-effect allele
- Freq: frequency of A1
- beta: effect of A1
- se: standard error of effect
- P: p-value