Dr. David Clarke's research group focuses on the application of modern techniques in mass spectrometry (MS) for the functional and structural characterisation of biological systems. The research utilises a range of MS-based techniques including - top-down and middle down fragmentation, ion-mobility mass spectrometry, native mass spectrometry, and hydrogen/deuterium exchange. In addition, MS-based studies are supported by complementary biochemical analysis and structural biology approaches.

Clarke Lab website

Items in this Collection

  • ESI-(-)-FT-ICR MS of 85 Scotch Whisky Samples 

    Kew, William; Uhrin, Dusan; Clarke, David; Goodall, Ian
    Data were acquired as part of research into advanced spectroscopic methods for the analysis of Scotch Whisky. 85 Scotch Whisky samples, representing the broad range of Scotch Whisky produced and sold, were analysed by ...
  • Top-Down Protein Electron Capture Dissociation Mass Spectrometry Datasets 

    Hughes, Sam; Clarke, David
    Top-down electron capture dissociation (ECD) fragmentation datasets for several widely available commerical protein samples. All data were collected on a 12T SolariX FT-ICR mass spectrometer (Bruker Daltonics); and data ...
  • Native MS Analysis of Encapsulated Ferritin from Rhodospirillum rubrum 

    Hughes, Sam; Vanden-Hehir, Sally; Clarke, David
    This dataset contains native MS analysis of the Encapsulated Ferritin (EncFtn, Rru_A0973) from Rhodospirillum rubrum. Included are ion-mobility mass spectra of apo- and Fe-bound EncFtn, mass spectral data showing the gas ...