To enhance fundamental knowledge of the control of cellular growth and differentiation aiming to underpin the development of better disease intervention strategies. We will advance our understanding of function in these essential biological processes through mechanistic studies at the cell, tissue and whole animal level with particular focus on:
- animal stem cells
- tissue and organ development
- tissue damage and repair
- regulatory networks in development
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Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation ...
(University of Edinburgh. Roslin Institute, 2013-03-26)Little is known about the involvement of microRNAs (miRNAs) in the follicular-luteal transition. The aim of this study was to identify genome-wide changes in miRNAs associated with follicular differentiation in sheep. miRNA ...