One medicine. To enhance understanding of disease processes in companion animals and to translate that understanding into improved therapies for both animal and human disease.

Items in this Collection

  • Cyclic compression of canine joint cells - microarray data 

    Johnson, Craig; Clements, Dylan
    Cells are agarose embedded and cyclically compressed on FXC compression bioreactor for 4 hours followed by 24 hours of recovery incubation. RNA extracted according to Bougault et al (2008) and canine microarray performed
  • Stimulation of canine joint cells to model osteoarthritis 

    Johnson, Craig; Clements, Dylan
    Canine chondrocytes and osteoblasts were embedded in an agarose matrix and simultaneously stimulated with cytokines whilst being cyclically compressed. Both cell types were compressed for 4 hours at 1 Hz followed by a 24 ...
  • Canine medial coronoid process disease microarray data 

    Johnson, Craig; Clements, Dylan
    The objective of this study was to identify differentially expressed genes associated with the process of medial coronoid process disease, primary to the development of osteoarthritis. The data were produced using Affymetrix ...
  • Cytokine stimulation of canine chondrocytes and osteoblasts 

    Johnson, Craig; Clements, Dylan
    In vitro modelling of osteoarthritis typically uses cytokines to induce a catabolic phenotype in joint cells. This model was used to identify the response to a cytokine parameter identified as most representative of early ...