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Depositordc.contributorKerr, Shona
Funderdc.contributor.otherMRC - Medical Research Councilen_UK
Spatial Coveragedc.coverage.spatialScotlanden_UK
Data Creatordc.creatorNagy, Reka
Data Creatordc.creatorBoutin, Thibaud
Data Creatordc.creatorMarten, Jonathan
Data Creatordc.creatorHayward, Caroline
Date Accessioneddc.date.accessioned2017-08-10T11:23:46Z
Date Availabledc.date.available2017-08-10T11:23:46Z
Citationdc.identifier.citationNagy, Reka; Boutin, Thibaud; Marten, Jonathan; Hayward, Caroline. (2017). Dataset 2 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants", [dataset]. University of Edinburgh, MRC Human Genetics Unit. http://dx.doi.org/10.7488/ds/2114.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/2788
Persistent Identifierdc.identifier.urihttp://dx.doi.org/10.7488/ds/2114
Dataset Description (abstract)dc.description.abstractThe Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across Scotland. Although data collection was cross-sectional, GS:SFHS became a prospective cohort due to the ability to link to routine Electronic Health Record (EHR) data. Over 20,000 participants were selected for genotyping using a genome-wide array. Genome-wide association studies (GWAS) were used to test the effects of a spectrum of variants, imputed using the Haplotype Research Consortium (HRC) dataset, on medically relevant traits measured directly or obtained from EHRs. The HRC dataset allowed investigation of variants with low minor allele frequencies in the entire GS:SFHS genotyped cohort. Genome-wide associations were run on 20,032 individuals using both genotyped and HRC imputed data. Results replicated known associations and additionally revealed novel findings, mainly with rare variants. The dataset contains genome-wide association summary statistics for this project. The other 11 data files can be found here: http://datashare.is.ed.ac.uk/handle/10283/2789en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh, MRC Human Genetics Uniten_UK
xmlui.dri2xhtml.METS-1.0.item-relation-ispartofdc.relation.ispartofhttp://datashare.is.ed.ac.uk/handle/10283/2789
Subjectdc.subjectGenome-wide association studies (GWAS)en_UK
Subjectdc.subjectElectronic health recordsen_UK
Subjectdc.subjectImputationen_UK
Subjectdc.subjectQuantitative traiten_UK
Subjectdc.subjectGeneticsen_UK
Subjectdc.subjectUrateen_UK
Subjectdc.subjectHeart rateen_UK
Subjectdc.subjectGlucoseen_UK
Subjectdc.subjectHaplotype Research Consortium (HRC)en_UK
Subject Classificationdc.subject.classificationBiological Sciencesen_UK
Titledc.titleDataset 2 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants"en_UK
Typedc.typedataseten_UK


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