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Depositordc.contributorSwain, Peter
Funderdc.contributor.otherBBSRC - Biotechnology and Biological Sciences Research Councilen_UK
Funderdc.contributor.otherEPSRC - Engineering and Physical Sciences Research Councilen_UK
Funderdc.contributor.otherWellcome Trusten_UK
Funderdc.contributor.otherMRC - Medical Research Councilen_UK
Funderdc.contributor.otherHuman Frontiers Science Programen_UK
Funderdc.contributor.otherCONACyten_UK
Time Perioddc.coverage.temporalstart=2014-11-01; end=2015-12-01; scheme=W3C-DTFen
Data Creatordc.creatorGranados, Alejandro
Date Accessioneddc.date.accessioned2017-05-05T09:58:07Z
Date Availabledc.date.available2017-05-05T09:58:07Z
Citationdc.identifier.citationGranados, Alejandro. (2017). Distributing tasks via multiple input pathways increases cellular survival in stress, 2014-2015 [dataset]. University of Edinburgh. http://dx.doi.org/10.7488/ds/2043.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/2708
Persistent Identifierdc.identifier.urihttp://dx.doi.org/10.7488/ds/2043
Dataset Description (abstract)dc.description.abstractData from single-cell microscopy experiments for "Distributing tasks via multiple input pathways increases cellular survival in stress" by Granados, Crane, Montano-Gutierrez, Tanaka, Voliotis, & Swain. Improving in one aspect of a task can undermine performance in another, but how such opposing demands play out in single cells and impact on fitness is mostly unknown. Here we study budding yeast in dynamic environments of hyperosmotic stress and show how the corresponding signalling network increases cellular survival both by assigning the requirements of high response speed and high response accuracy to two separate input pathways and by having these pathways interact to converge on Hog1, a p38 MAP kinase. Cells with only the less accurate, reflex-like pathway are fitter in sudden stress, whereas cells with only the slow, more accurate pathway are fitter in fluctuating but increasing stress. Our results demonstrate that cellular signalling is vulnerable to trade-offs in performance, but that these trade-offs can be mitigated by assigning the opposing tasks to different signalling subnetworks. Such division of labour could function broadly within cellular signal transduction.en_UK
Dataset Description (TOC)dc.description.tableofcontentsText files of single-cell data in six ramps and six steps of osmotic stress for wild-type and STE11 and SSK1 deletion mutants of budding yeast. See README.txt.en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburghen_UK
Subjectdc.subjectOsmotic stressen_UK
Subjectdc.subjectBudding yeasten_UK
Subjectdc.subjectMAP kinaseen_UK
Subjectdc.subjectHog1en_UK
Subjectdc.subjectNuclear translocationen_UK
Subjectdc.subjectVolumeen_UK
Subjectdc.subjectSingle cellen_UK
Subjectdc.subjectMicrofluidicsen_UK
Subject Classificationdc.subject.classificationBiological Sciencesen_UK
Titledc.titleDistributing tasks via multiple input pathways increases cellular survival in stressen_UK
Typedc.typedataseten_UK

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