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Depositordc.contributorCachat, Elise
Funderdc.contributor.otherBBSRC - Biotechnology and Biological Sciences Research Councilen_UK
Funderdc.contributor.otherLeverhulme Trusten_UK
Data Creatordc.creatorCachat, Elise
Data Creatordc.creatorDavies, Jamie
Date Accessioneddc.date.accessioned2017-03-01T12:37:58Z
Date Availabledc.date.available2017-03-01T12:37:58Z
Citationdc.identifier.citationCachat, Elise; Davies, Jamie. (2017). Data supporting Cachat et al. (2017): "Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development", [dataset]. University of Edinburgh. College of Medicine and Veterninary Medicine. Centre for Integrative Physiology. http://dx.doi.org/10.7488/ds/1978.en
Persistent Identifierdc.identifier.urihttp://hdl.handle.net/10283/2632
Persistent Identifierdc.identifier.urihttp://dx.doi.org/10.7488/ds/1978
Dataset Description (abstract)dc.description.abstractThese are raw image datasets used in a manuscript (Cachat et al., 2017: Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development) with the following abstract: This paper reports a proof-of-concept study as a step toward synthetic-biological morphogenesis of tissues. Events in normal animal development usually follow the sequence: patterning → differential gene expression → morphogenesis. A synthetic biological approach to development would follow the same sequence, with each stage under the control of synthetic biological modules. We have constructed and published a synthetic module that drives self-organized patterning of mammalian cell populations, and a library of modules that drive different types of morphogenetic events. Here, as a proof of concept, we couple a self-patterning module with a morphogenetic effector driving elective cell death. The result is a self-constructing pattern of two cell types, one of which can be selectively eliminated to leave remaining cells as a monolayer with net-like structure. This simple device demonstrates and validates the idea of coupling synthetic biological morphogenetic effectors to synthetic biological patterning devices, and opens the path to engineering more sophisticated structures and, perhaps eventually, tissues.en_UK
Dataset Description (TOC)dc.description.tableofcontentsThere is one zipped file containing original images included in Cachat et al. (2017) Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development (submitted).en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburgh. College of Medicine and Veterninary Medicine. Centre for Integrative Physiologyen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyCachat et al. (2017) "Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development", submitteden_UK
Superseded Bydc.relation.isreplacedbyhttp://datashare.is.ed.ac.uk/handle/10283/2728
Subjectdc.subjectsynthetic morphologyen_UK
Subjectdc.subjectpatterningen_UK
Subjectdc.subjectapoptosisen_UK
Subjectdc.subjectself-organizationen_UK
Subjectdc.subjectsynthetic tissueen_UK
Subject Classificationdc.subject.classificationBiological Sciences::Developmental Biologyen_UK
Titledc.titleSUPERSEDED - Data supporting Cachat et al. (2017): "Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development"en_UK
Typedc.typedataseten_UK

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