• RNA composition metrics 

    Simmonds, Peter
    Mutating RNA virus genomes to alter codon pair (CP) frequencies and reduce translation efficiency has been advocated as a method to generate safe, attenuated virus vaccines. However, selection for disfavoured CPs leads to ...
  • Somatic Cell Nuclear Transfer (Cloning) Efficiency 

    Wilmut, Ian; Paterson, LA
    Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation ...