Nair, Harish. (2016). Global, regional and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015, 1995-2015 [dataset]. University of Edinburgh. Usher Institute of Population Health Sciences and Informatics..
We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory
infection (ALRI) resulting in 55,000 to 199,000 deaths in children younger than five years in 2005. In the last five years, there has been
considerable RSV research activity yielding substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration we aimed to estimate the global incidence, hospitalisation rate and mortality from RSV-ALRI episodes in young children in 2015.
We estimated the incidence and hospitalisation rate of RSV-associated ALRI (RSV-ALRI) in children younger than five years stratified by age and World Bank income regions from a systematic review of studies published between January 1995 and August 2015, and unpublished data from high quality population-based studies. We estimated the RSV-ALRI incidence for
developing countries using a risk factor based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by
combining in-hospital CFRs with hospitalisation estimates from hospitalbased (published and unpublished) studies. We also estimated overall RSVALRI mortality by identifying studies reporting monthly data on ALRI mortality in the community and RSV activity.